Do not use a Bunsen burner because ethanol is flammable. �gz�܁]"��K�e]��u�H1�1��6p�����7��^}�{J��0HL��ϔ�|���#f_�j �b���r�z���g���O��C�B+y�L�5�U�P�����&pQ8)�6yr�G�d)ʢ ��B�虼wy��@�*��M����ċ{R�x]��O�#�-��r=U���]G�nH�& #����g>V��DV l�V-�E�@�Kxk�T[�o�k���z��A�V�B�dA�{e�!G��y�OUl}|�ve,59�[�0��s�;�-�/��+�������r-�SH��� ��**��h-��%�� Ҫ�]�(� Festival of Sacrifice: The Past and Present of the Islamic Holiday of Eid al-Adha. After synthesis, the sample will be purified by recrystallization meth-ods. 3.0 g salicylic acid; 6 mL acetic anhydride* 5-8 drops of 85% phosphoric acid or concentrated sulfuric acid* Distilled water (about 50 mL) 10 mL ethanol; 1% iron III chloride (optional, to test purity) *Use extreme caution when handling these chemicals. First, gather the chemicals and equipment used to synthesize the aspirin. 1 0 obj A “purified product” can be obtained through recrystallization of the crude product in hot, Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as, a pain killer. ����zV��e �,r��}�CCM9���nP�"���ST>4 The synthesis reaction of aspirin is shown below: The spectroscopic analysis of aspirin will involve the complexing of iron(III) to the deprotonated form of. %���� The chemical equation for the synthesis of aspirin is C7H6O3 + C4H6O3 –> C9H8O4 +C2H4O2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid. The synthesis reaction of aspirin is shown below: The spectroscopic analysis of aspirin will involve the complexing of iron(III) to the deprotonated form ofsalicylic acid (salicylate ion) to give a purple solution. Heat the water bath to boiling and keep it at this temperature for around 10 minutes, Add 2ml of distilled water to destroy remaining acetic anhydride. For the synthesis of aspirin, how do you calculate the percent yield if the reaction produces 4.70 grams of aspirin. Aspirin or ASA (acetylsalicylic acid) can be synthesized by turning the hydroxyl group of salicylic acid into an ester group (R-OH → R-OCOCH 3) In the body, however, aspirin is again metabolized to salicylic acid, which is the active ingredient; The product can be tested for purity, by adding ferric chloride to an aqueous solution. The results section will present all the numerical data necessary for this experi-ment (synthesis of aspirin masses, theoretical yield, percent yield and error, and TLC analysis). endobj SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. To prepare aspirin, salicylic acid is reacted with an excess of aceticanhydride. 3. e�:{�L���DR��d{։�����Hd��)B�! 3 0 obj <>>> Will 5G Impact Our Cell Phone Plans (or Our Health?! equation is displayed below. The most common way to prepare aspirin is by using Acid Anhydrides and by reacting acetic acid with salicylic acid. The molecular geometry of aspirin is planar and its molecular mass is 180.159 g/mol. precipitate when water is added. Aspirin, or acetylsalicylic acid, is one of the oldest and most common medications worldwide. � F�5:t�5VH2?�sb8c.���w��%Wp���[0�FL��f.upqG1�9�}j�s�����ߍ-�áWi�<�|Ĕ�S ���ZkϹ�*��.Ƃ�̩. equation). Page 2 of 5 Warning: The aspirin … Add 10 mL of ethanol and gently warm the mixture on a hot plate to dissolve. The reaction, using molecular formulas is C7H6O3 + C4H6O3 --> C9H8O4 … endobj The aspirin product is not very soluble in water so the aspirin product willprecipitate when water is added. The structural formula of aspirin or Acetylsalicylic acid is represented as- Aspirin is extensively used in the pharmaceutical sector. *6A�8y�=nI)�!��[rSo���i4YO�D���^�I�,�|�L���GZ�8��K�j�O�� The reaction for the synthesis is given below. endobj 4 0 obj H 3PO 4 C 4H 6O 3 + C 7H 6O 3 → C 9H 8O 4 + HC 2H 3O 2 Acetic Salicylic Aspirin Acetic Acid Anhydride Acid This can be expanded to the following structures: Note: Carbons (and hydrogens) are implied where lines (bonds) meet. As the solution cools, crystals of aspirin will appear. Aspirin Synthesis Materials . A small amount of a strong acid is used as a catalyst that speeds up the reaction. In thisexperiment, phosphoric acid will be used as the catalyst. Transfer 20 drops of this aspirin-ethanol solution into tube A. 1Taken fromSynthesis and Analysis of Aspirin, UCLA Chemistry Department. The purity of the sample will then be ana-lyzed using TLC. Only the salicylate ion complexes to iron(III). x��Z�n�F}7��G)���xxn� 6���0�-�YVHN�7����i���X�/Wo�����׫ۗMq�)(�yS>�g3���[������J2���gJH�_�ȄA��H! stream salicylic acid (salicylate ion) to give a purple solution. �.�T� Z��S@xM���.��� C��P�;}�bW-u۞^�,��h���,i� lj�cV�2 dҷ���(H�7�g^p��H0'�~T I�@�%Rp��NK\� ���:�.CL�@�ԋM�j{s�woa�_��<3���T��{��m����2f�k^@�ao��I#Ț�%�xl���E-�n����&�K�UF�+���m�����Ș ��Ƕ9����k�ź���ޠ�X_M/]G���.��m_���歝�p��o��� �� %PDF-1.5 <> ), The Secret Science of Solving Crossword Puzzles, Racist Phrases to Remove From Your Mental Lexicon. Reagent A – Weigh 1.00 g of the aspirin product into a 50 mL beaker. Salicylic acid, whose name comes from Salix, the willow family of plants, was derived from, To prepare aspirin, salicylic acid is reacted with an excess of acetic, anhydride. The excess acetic acid will be quenched with, the addition of water. <>/XObject<>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> H 2 SO 4 (use a dropper, H2SO4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves. Add 10 mL of Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. In this, experiment, phosphoric acid will be used as the catalyst. Salicylic acid, whose name comes from Salix, the willow family of plants, was derived fromwillow bark extracts. The chemical equation for the synthesis of aspirin is C7H6O3 + C4H6O3 –> C9H8O4 +C2H4O2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid.