- Low serum iron cannot be interpreted in isolation because it might be seen in infection, inflammation, and malignancy as well as iron deficiency.5 We recommend measuring C reactive protein if serum ferritin is normal or high with serum iron or transferrin saturation below their … Ferritin and total iron testing will have low results. There are several ways people can experience low transferrin saturation because of or despite their diet containing low iron saturation: Individuals who want to incorporate more iron into their diet can try eating leafy greens, meat, eggs and iron fortified foods. Sign up to receive the latest and greatest articles from our site automatically each week (give or take)...right to your inbox. Causes iron deficiencyIron deficiency can be the result of numerous and multiple causes. There are several blood tests that can help in determining the level of iron in the body. Pag 519. 39. This iron blood test panel measures the hemoglobin, ferritin, fasting serum iron, TIBC (total iron binding capacity) and transferrin levels. Find the underlying cause for low iron saturation. Except for those who are strict vegetarians, men rarely have dietary iron deficiency. The transferrin saturation percentage could be near 0 % in severe anemia. ®. In the same way high iron content than what is required in the body is also detrimental to health. Lack of gastric intrinsic factor can inhibit the absorption of vitamin B12 which in turn could affect the absorption of iron. The ranges can be different depending on the laboratory or on your personal circumstances. Some people may also experience problems with their heart and there may be a partial or complete loss of a sex drive. While TIBC is the total amount of iron that can be bound and transported by transferrin, serum iron is the total amount of iron in the blood. How iron deficiency is detected and diagnosed The tests used most often to detect iron deficiency include hemoglobin (the iron-containing protein in the blood), serum ferritin, which indicates the amount of iron stored in the body, and serum iron and iron-binding capacity (IBC, UIBC or TIBC). Iron deficiency without anemia can occur when a person has a normal hemoglobin, but below normal serum ferritin and/or transferrin saturation. Clinical chemistry and laboratory medicine: CCLM / FESCC. Diseased states that reduce the presence of iron in the body include extensive cancer, uremia, nephrotic syndrome and tissue inflammation states. Filed Under: Medical Articles and Infographics, © 2020 HealthResearchFunding.org - Privacy Policy, 14 Hysterectomy for Fibroids Pros and Cons, 12 Pros and Cons of the Da Vinci Robotic Surgery, 14 Pros and Cons of the Cataract Surgery Multifocal Lens, 11 Pros and Cons of Monovision Cataract Surgery. In cases of iron deficiency anemia, iron supplements can be helpful; but in cases of anemia of chronic disease, iron supplements could be harmful. People suffering from a chronic illness will typically have low iron levels in all blood tests that are ordered, though ferritin levels can sometimes be high during an illness. If you suspect an iron deficiency, before having a blood test ordered, it is important to speak with your doctor about any chronic pain, infections, or inflammation that are present. Vegetarians are more vulnerable for iron deficiency for that matter. Heavy blood flow during menstruation is generally a cause for anemia in women. Would you like to write for us? Other nutrients, however, such as vitamins C and B12, folate or zinc can facilitate sufficient non-heme iron absorption. A range below 50 ng(ml) ferritin can also indicate a trend toward iron deficiency, and a range above 150ng(ml) can indicate an excess of iron, which is also cause for concern. For more questions about the iron saturation blood test and how it may impact your health, be sure to speak with your doctor and review your complete medical history for best results. On the other hand, TSAT percentage will be low if iron absorption is low. Transferrin saturation (TSAT), which is also referred to as iron saturation, is a valuable diagnostic test that helps to determine if the body is transporting or binding iron in the right manner or not. Sideroblastic Anemia: This health condition also has a high saturation percentage. The Dangers Involving Low Iron Levels. The meaning of iron saturation is body’s ability to transport iron or bind iron. Maybe iron deficient: Low iron saturation could indicate an overall iron deficiency, but there are other blood tests that need to be done to determine … TSAT should be 15-50% for males and 12-45% for females. It will also produce a high abnormal result on a ferritin blood test. These cookies will be stored in your browser only with your consent. Under normal circumstances, serum iron must lie between 60 to 170 μg/dl, whereas reference range for TIBC is 240-450 μg/dl. Total iron-binding capacity short form is TIBC. Heme iron is absorbed more efficiently than non-heme iron found in plants and dietary supplements. Normal transferrin saturation level in the blood. Vegetarians have to depend on foods that contain iron such as green vegetables, spinach, dates, apricot, jaggery, beetroot, grains and beans etc. Iron deficiency can result in poor memory or poor cognitive skills (mental function) and can result in poor performance in school, work,and in military or recreational activities. If iron absorption is abnormally high, transferrin gets saturated with iron. Low iron in body is responsible for many unwanted conditions. Hemolytic Anemia: This condition is represented by a high saturation percentage and a high iron and ferritin count. World journal of pediatrics : WJP. Hemochromatosis: This health condition will have a high iron saturation rate. If the laboratory test shows low level of iron saturation and low serum iron, it indicates iron deficiency anemia. Fundamentals of Clinical Chemistry. Men are rarely iron deficient; but when they are, it is generally due to blood loss from the digestive tract (sometimes indicating disease), diseases that affect iron absorption, and in some cases, alcohol abuse. Which factors can reduce the transferrin saturation? Iron is an essential nutrient which is why there’s a great need to include sources of iron in one’s diet in the required quantity. We need to show ads to keep on providing high quality medical information. Intestinal disorders could affect the process of iron absorption thereby lowering the TSAT levels. What is low transferrin saturation percentage called? Abnormally high levels of iron in the blood and high TSAT are indicative of hemochromatosis or iron poisoning. The nutrients from our food are absorbed by the intestine. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. The iron saturation blood test is typically ordered when there is the possibility of a deficiency or an overload of iron for some reason. Some people with significant iron deficiency might require iron infusions or whole blood transfusions to restore iron sufficiency. Parasitic infestations, blood loss due to hemorrhoids can also cause low level of iron in the blood. Meat, fish, eggs, and poultry are rich source of iron. The transferrin saturation percentage is very low. Although it does not directly yield any energy, iron is a mineral that plays a number of life-sustaining roles in your body. It is a test that is often ordered with other iron measurements to determine if there may be a deficiency present or if a person’s bothersome signs and symptoms are due to iron toxicity. This person is usually unable to absorb iron, regardless of how much he eats. Another important cause for low saturation of iron is when you have intestine problem. 40. Links to more information about iron deficiency: US Centers for Disease Control and Prevention MMWR (CDC Morbidity and Mortality Weekly Report, https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5140a1.htm, US Centers for Disease Control and Prevention Division of Nutrition, https://www.cdc.gov/nutrition/index.html https://www.cdc.gov/nutrition/micronutrient-malnutrition/index.html https://www.cdc.gov/nutrition/micronutrient-malnutrition/micronutrients/index.html https://www.cdc.gov/nccdphp/dnpao/index.html, The Agency for Healthcare and Research Quality (AHRQ), Gerry Koenig - The Dangers of Misdiagnosis. https://www.cdc.gov/nutrition/micronutrient-malnutrition/index.html, https://www.cdc.gov/nutrition/micronutrient-malnutrition/micronutrients/index.html, https://www.cdc.gov/nccdphp/dnpao/index.html, Follow an Iron-Deficiency Patient at getyourironup.com. 122-6. This will help a medical provider be able to determine what potential disease or deficiency may be present. https://www.hematology.org/education/patients/anemia/iron-deficiency A diagnosis of iron deficiency can be made when a person has both low hemoglobin and hematocrit and low serum ferritin. TSAT should be 15-50% for males and 12-45% for females. The body’s ability to absorb iron might be adversely affected due to intestinal disorders such as celiac disease or Crohn’s disease. People who undergo gastric bypass surgery are only able to eat small meals, which may prevent them from getting enough iron into their diets. TSAT, which is measured as a percentage, is calculated by dividing the level of serum iron by the total iron binding capacity (TIBC) and multiplying by 100. If transferrin saturation is below the reference range, one must replenish body’s iron stores by following a healthy diet. Usually your doctor advises three tests together, iron saturation, total iron binding capacity (TIBC), and serum iron. What makes iron such an interesting supplement in nutritional health is the fact that only about 10% of the iron a person consumes every day will be absorbed by the body. Ferritin and total iron testing will have low results. The types of anemias that shows a low percentage of transferrin saturation are iron-deficiency anemia and anemia of the chronic disease. Iron deficiency is the most common nutritional deficiency and the leading cause of anemia in the world. Since excessive consumption of foods that are rich in calcium can inhibit iron absorption, it would be a good idea to cut down on your intake of dairy products or calcium supplements. (2002). To learn more about these tests visit tests to determine iron levels. The total iron-binding capacity It is the amount of iron that is in demand to fully saturate transferrin. It also plays a vital role in energy production and the synthesis of DNA. To normalize the iron saturation in the blood, a person has to eat iron containing food. Other symptoms that might be experienced include lightheadedness, pale skin, low blood pressure, irritability, sore tongue or abdominal pain.